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-synuclein, which can be a principal component of Lewy bodies, in PARK one in 1997 and parkin in PARK 2 in 1998, that's an E3 ubiquitin ligase and results in endoplasmic reticulum (ER) pressure, counsel that dysfunction on the intracellular proteinase devices, for example ubiquitin-proteasome technique or lysosomal method, which eliminates unnecess

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